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What’s in the Book?
The culmination of over 25 years' expertise in nucleic acid chemistry.
Includes comprehensive background information and literature citations, detailed application information, and extensive protocols and physical data for everyday use.
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GUIDEBOOK FOR THE SYNTHESIS OF OLIGONUCLEOTIDES
This 192-page guide will tell you everything you need to know about oligo synthesis & applications.
"My research group is concerned with developing RNA aptamers against various biological targets, and so in my role, keeping up to date with the latest advancements in nucleic acid modifications and reagents is vital. For me, the LINK Guidebook is extremely useful – especially the protocols section - but the handy working examples and further external referencing are also an easy port-of-call when I’m required to synthesize new oligos.”
Amy Barker, Research Technician, University of Leeds
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SUMMARY CONTENTS
Ordering Information
16
Chemistry of Oligonucleotide Synthesis
24
Oligonucleotide Synthesis Cycle
24
Choosing a Solid Support
28
Protection Group Strategies
30
Oligoribonucleotide Synthesis
32
Alternative Activators
34
Bespoke 3'-incorporation
35
Modifiers and Their Use in Oligonucleotide Synthesis
36
Introduction
78
Diagnostics
78
Fluorescence Detection
78
Colourimetric Detection & Capture
91
Electrochemical Detection
93
Branching Modification
94
Therapeutics
99
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Introduction
Spacers
Conjugation Reagents
Backbone Modification
Using Photocleavable (PC) Modifiers
Modifications for Nuclease Resistance
70
66
53
39
36
36
Chemical Phosphorylation
76
Applications of Modified Oligonucleotides
Antisense Therapy
99
siRNA
101
78
Indices
180
Glossary
176
Physical Data
170
Oligonucleotide Synthesis & Bioconjuation Protocols
116
Structural Studies
107
Cell Delivery and Uptake
101