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The culmination of over 25 years' expertise in nucleic acid chemistry.

Includes comprehensive background information and literature citations, detailed application information, and extensive protocols and physical data for everyday use.

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GUIDEBOOK FOR THE SYNTHESIS OF OLIGONUCLEOTIDES

This 192-page guide will tell you everything you need to know about oligo synthesis & applications.

"My research group is concerned with developing RNA aptamers against various biological targets, and so in my role, keeping up to date with the latest advancements in nucleic acid modifications and reagents is vital. For me, the LINK Guidebook is extremely useful – especially the protocols section - but the handy working examples and further external referencing are also an easy port-of-call when I’m required to synthesize new oligos.”

Amy Barker, Research Technician, University of Leeds
 

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SUMMARY CONTENTS

Ordering Information

16

Chemistry of Oligonucleotide Synthesis

24

Oligonucleotide Synthesis Cycle

24

Choosing a Solid Support

28

Protection Group Strategies

30

Oligoribonucleotide Synthesis

32

Alternative Activators

34

Bespoke 3'-incorporation

35

Modifiers and Their Use in Oligonucleotide Synthesis

36

Introduction

78

Diagnostics

78

Fluorescence Detection

78

Colourimetric Detection & Capture

91

Electrochemical Detection

93

Branching Modification

94

Therapeutics

99

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Introduction

Spacers

Conjugation Reagents

Backbone Modification

Using Photocleavable (PC) Modifiers

Modifications for Nuclease Resistance

70

66

53

39

36

36

Chemical Phosphorylation

76

Applications of Modified Oligonucleotides

Antisense Therapy

99

siRNA

101

78

Indices

180

Glossary

176

Physical Data

170

Oligonucleotide Synthesis & Bioconjuation Protocols

116

Structural Studies

107

Cell Delivery and Uptake

101

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